Could SARS-CoV-2-induced hyperinflammation magnify the severity of coronavirus disease (CoViD-19) leading to acute respiratory distress syndrome?

ASS Girija, EM Shankar, M Larsson - Frontiers in immunology, 2020 - frontiersin.org
The exaggerated immune response induced in the lower respiratory tract against
coronaviruses (CoVs), including CoViD-19 (2019-nCoV), appears to contribute to the …

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?

MJ Ombrello, GS Schulert - Translational Research, 2021 - Elsevier
Although interest in “cytokine storms” has surged over the past decade, it was massively
amplified in 2020 when it was suggested that a subset of patients with COVID-19 developed …

[HTML][HTML] Severe COVID-19: what have we learned with the immunopathogenesis?

B Bordallo, M Bellas, AF Cortez, M Vieira… - Advances in …, 2020 - SciELO Brasil
The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has become a global major concern. In this review, we addressed a theoretical …

Comparative survival analysis of immunomodulatory therapy for coronavirus disease 2019 cytokine storm

S Narain, DG Stefanov, AS Chau, AG Weber, G Marder… - Chest, 2021 - Elsevier
Background Cytokine storm is a marker of coronavirus disease 2019 (COVID-19) illness
severity and increased mortality. Immunomodulatory treatments have been repurposed to …

Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection

S Keam, D Megawati, SK Patel, R Tiwari… - Reviews in Medical …, 2020 - Wiley Online Library
The outbreak of coronavirus disease 2019 (COVID‐19) and pandemic, caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has become a major concern …

Humoral immune mechanisms involved in protective and pathological immunity during COVID-19

G Widjaja, AT Jalil, HS Rahman, WK Abdelbasset… - Human Immunology, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 is
associated with excessive inflammation, as a main reason for severe condition and death …

Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently
emerged in Wuhan, Hubei-China, as responsible for the coronavirus disease 2019 (COVID …

[HTML][HTML] COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis

KM Sohn, SG Lee, HJ Kim, S Cheon… - Journal of Korean …, 2020 - ncbi.nlm.nih.gov
Background Observational studies of the ongoing coronavirus disease 2019 (COVID-19)
outbreak suggest that a 'cytokine storm'is involved in the pathogenesis of severe illness …

An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis

Y Liu, D Chen, J Hou, H Li, D Cao, M Guo, Y Ling… - Cytokine, 2021 - Elsevier
The hyper-inflammatory response is thought to be a major cause of acute respiratory
distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are …

Definition and risks of cytokine release syndrome in 11 critically ill COVID-19 patients with pneumonia: analysis of disease characteristics

W Wang, X Liu, S Wu, S Chen, Y Li… - The Journal of …, 2020 - academic.oup.com
Abstract Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities
are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of …