Protoporphyrin IX-induced phototoxicity: Mechanisms and therapeutics
Protoporphyrin IX (PPIX) is an intermediate in the heme biosynthesis pathway. Abnormal
accumulation of PPIX due to certain pathological conditions such as erythropoietic …
accumulation of PPIX due to certain pathological conditions such as erythropoietic …
[HTML][HTML] Experimental and approved treatments for skin photosensitivity in individuals with erythropoietic protoporphyria or X-linked protoporphyria: A systematic …
Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are characterized by
skin photosensitivity caused by accumulation of protoporphyrin IX. We aimed to review the …
skin photosensitivity caused by accumulation of protoporphyrin IX. We aimed to review the …
Protoporphyrin IX stimulates melanogenesis, melanocyte dendricity, and melanosome transport through the cGMP/PKG pathway
J Lv, X An, S Jiang, Y Yang, G Song… - Frontiers in …, 2020 - frontiersin.org
Protoporphyrin IX (PPIX) is a heterocyclic organic compound that is the last intermediate in
the heme biosynthetic pathway. PPIX, due to its photodynamic effects, is utilized in the …
the heme biosynthetic pathway. PPIX, due to its photodynamic effects, is utilized in the …
A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose‐controlled delivery of the prodrugs 5‐aminolaevulinic acid …
S Gerscher, JP Connelly… - British Journal of …, 2001 - academic.oup.com
Background Topical 5‐aminolaevulinic acid (ALA) is widely used in photodynamic therapy
(PDT) to generate protoporphyrin IX (PpIX) in the skin. However, other prodrugs may be …
(PDT) to generate protoporphyrin IX (PpIX) in the skin. However, other prodrugs may be …
[HTML][HTML] Cimetidine for erythropoietic protoporphyria
IM Heerfordt, CM Lerche, HC Wulf - Photodiagnosis and Photodynamic …, 2022 - Elsevier
Background Erythropoietic protoporphyria (EPP) is caused by deficiency of the enzyme
converting protoporphyrin IX (PpIX) into heme resulting in accumulation of PpIX; leading to …
converting protoporphyrin IX (PpIX) into heme resulting in accumulation of PpIX; leading to …
[PDF][PDF] Protoporphyrin photosensitivity cannot be attenuated by oral N-acetylcysteine
JC Bijlmer-Iest, H Baart de la Faille… - …, 1992 - researchgate.net
The photodermatosis in erythropoietic protoporphyria (EPP) is caused by the accumulation
of photosensitizing protoporphyrin (PP) in the skin, due to a defect in ferrochelatase, the …
of photosensitizing protoporphyrin (PP) in the skin, due to a defect in ferrochelatase, the …
[HTML][HTML] Protoporphyrin IX induces a necrotic cell death in human THP-1 macrophages through activation of reactive oxygen species/c-Jun N-terminal protein kinase …
H Xu, Y Sun, Y Zhang, W Wang, J Dan, J Yao… - Cellular Physiology and …, 2014 - karger.com
Background: Protoporphyrin IX (PpIX) and its derivatives are widely used in photodynamic
therapy (PDT) to kill cancer cells. Studies showed that the application of these drugs could …
therapy (PDT) to kill cancer cells. Studies showed that the application of these drugs could …
Comparison of the Pharmacokinetics and Phototoxicity of Protoporphyrin IX Metabolized from 5‐Aminolevulinic Acid and Two Derivatives in Human Skin In Vivo¶
S Gerscher, JP Connelly, J Griffiths… - Photochemistry and …, 2000 - Wiley Online Library
Our novel approach was to compare the pharmacokinetics of 5‐aminolevulinic acid (ALA),
ALA‐n‐butyl and ALA‐n‐hexylester induced protoporphyrin IX (PpIX), together with the …
ALA‐n‐butyl and ALA‐n‐hexylester induced protoporphyrin IX (PpIX), together with the …
In vivo measurement of 5‐aminolaevulinic acid‐induced protoporphyrin IX photobleaching: a comparison of red and blue light of various intensities
V Nadeau, M O'Dwyer, K Hamdan… - Photodermatology …, 2004 - Wiley Online Library
Background: In recent years, 5‐aminolaevulinic acid (ALA) has become an increasingly
popular photosensitizing drug for use in both photodynamic therapy (PDT) and …
popular photosensitizing drug for use in both photodynamic therapy (PDT) and …
Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria
Erythropoietic protoporphyria (EPP) is a rare disease in which patients experience severe
light sensitivity. It is caused by a deficiency of ferrochelatase (FECH), the last enzyme in …
light sensitivity. It is caused by a deficiency of ferrochelatase (FECH), the last enzyme in …