We examined events associated with neuronal differentiation of neuroblastoma cell line SH-
SY5Y. Treatment with nerve growth factor (NGF) and aphidicolin, an inhibitor of DNA …

The human trkA cDNA was transfected into a malignant human neuroblastoma (NB) cell line
(HTLA230) to investigate its role in NB growth and differentiation. This cell line lacks …

Functional nerve growth factor (NGF) responsiveness was investigated in human
neuroblastoma (NB) cell lines in vitro and retinoic acid (RA) was found to transcriptionally …

Human neuroblastoma cell lines frequently express the TRK-A proto-oncogene and bind
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …

Cells that lack the high affinity receptor component (trkA) for nerve growth factor (NGF) are
unresponsive to NGF. We investigated whether C6‐2B cells, a rat glioma derived cell line …

The trkA gene encodes the tyrosine kinase receptor that transduces the NGF signal. We
have used a defective herpes simplex virus-1 (HSV-1) vector containing a full-length rat trkA …

The induction of growth inhibition and differentiation of a glioma cell line by transfection of trk
A cDNA was examined, and production of endogenous nerve growth factor (NGF) also was …

Activation of the neurotrophin receptor TrkA by its ligand nerve growth factor (NGF) initiates
a cascade of signaling events leading to neuronal differentiation in vitro and might play an …

The effect of constitutively expressed N-myc gene on nerve growth factor (NGF) induced
neuronal differentiation was investigated. B104, a rat central nervous system-derived cell …

Two classes of receptors with distinct affinities for nerve growth factor (NGF) have been
identified. The low affinity receptor (Kd-= 10. 9 to 10-aM) is a cysteinerich glycoprotein …