One major limitation of neutralizing antibody-based COVID-19 therapy is the requirement of
costly cocktails to reduce emergence of antibody resistance. Here we engineer two …

Neutralizing antibodies (nAbs) hold promise as therapeutics against COVID-19. Here, we
describe protein engineering and modular design principles that have led to the …

Abstract COVID-19 pathogen SARS-CoV-2 has infected hundreds of millions and caused
over 5 million deaths to date. Although multiple vaccines are available, breakthrough …

Rapid emergence of new variants of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has prompted an urgent need for the development of broadly applicable and …

Structural principles underlying the composition and synergistic mechanisms of protective
monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity …

Virus-neutralizing antibodies are one of the few treatment options for COVID-19. The
evolution of SARS-CoV-2 virus has led to the emergence of virus variants with reduced …

In vitro antibody selection against pathogens from naïve combinatorial libraries can yield
various classes of antigen-specific binders that are distinct from those evolved from natural …

The COVID-19 pandemic is a major threat to global health for which there are only limited
medical countermeasures, and we lack a thorough understanding of mechanisms of …

Dear Editor, The ongoing COVID-19 pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in unprecedented public health and …

Introduction The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants has caused unprecedented health and socioeconomic crises, necessitating …