Hypothesis for the management and treatment of the COVID-19-induced acute respiratory distress syndrome and lung injury using mesenchymal stem cell-derived …

M Taghavi-Farahabadi, M Mahmoudi, S Soudi… - Medical hypotheses, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the
coronaviridae that causes respiratory disorders. After infection, large amounts of …

Longitudinal trend of plasma concentrations of extracellular vesicles in patients hospitalized for COVID-19

E Campello, CM Radu, C Simion, L Spiezia… - Frontiers in Cell and …, 2022 - frontiersin.org
Plasma concentrations of extracellular vesicles (EVs) originating from cells involved in
COVID-19-associated coagulopathy (CAC), their longitudinal trend and association with …

Exosomes recovered from the plasma of COVID-19 patients expose SARS-CoV-2 spike-derived fragments and contribute to the adaptive immune response

E Pesce, N Manfrini, C Cordiglieri, S Santi… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by beta-coronavirus
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has rapidly spread …

Possibility of exosome‑based coronavirus disease 2019 vaccine

KH Yoo, N Thapa, BJ Kim, JO Lee… - Molecular …, 2022 - spandidos-publications.com
Abstract Coronavirus disease 2019 (COVID‑19) is a global pandemic that can have a long‑
lasting impact on public health if not properly managed. Ongoing vaccine development trials …

Clinical applications for exosomes: Are we there yet?

D Perocheau, L Touramanidou… - British journal of …, 2021 - Wiley Online Library
Exosomes are a subset of extracellular vesicles essential for cell–cell communication in
health and disease with the ability to transport nucleic acids, functional proteins and other …

[PDF][PDF] Serum‐derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID‐19 patients

T Tertel, S Tomić, J Đokić, D Radojević… - Journal of …, 2022 - Wiley Online Library
COVID‐19 is characterized by a wide spectrum of disease severity, whose indicators and
underlying mechanisms need to be identified. The role of extracellular vesicles (EVs) in …

[PDF][PDF] Re:" exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID-19" by Sengupta et al.

SK Lim, B Giebel, DJ Weiss, KW Witwer… - Stem Cells Dev, 2020 - researchgate.net
However, these need to be developed in a transparent way including rigorous peer-
reviewed and appropriately conducted, regulated, and reported clinical investigations …

Therapeutic potential of extracellular vesicles for sepsis treatment

SM Kronstadt, AE Pottash, D Levy, S Wang… - Advanced …, 2021 - Wiley Online Library
Sepsis is a deadly condition lacking a specific treatment despite decades of research. This
has prompted the exploration of new approaches, with extracellular vesicles (EVs) emerging …

Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

Red blood cell-derived extracellular vesicles display endogenous antiviral effects and enhance the efficacy of antiviral oligonucleotide therapy

MK Jayasinghe, C Gao, G Yap, BZJ Yeo, LT Vu… - ACS …, 2023 - ACS Publications
The COVID-19 pandemic has resulted in a large number of fatalities and, at present, lacks a
readily available curative treatment for patients. Here, we demonstrate that unmodified red …