The COVID-19 pandemic has placed the practice of medicine at a threshold overlooking a
new and different era, 1 and has led to the evolving concept of COVID-19 cytokine storm …

At present, healthcare systems all over the world are coping with the new coronavirus
infection [1]. In particular, tremendous efforts are are being made in order to support …

1 Kalfaoglu B, Almeida-Santos J, Tye CA, Satou Y, Ono M. T-cell hyperactivation and
paralysis in severe COVID-19 infection revealed by single-cell analysis. Front Immunol …

Patients with immune-mediated inflammatory diseases are at a higher risk of severe COVID-
19, in part, due to immune suppression induced by treatment. 1, 2 France began …

Hyperinflammation is a key component of severe COVID-19, residing underneath the
cytokine storm umbrella term, associated with poor outcomes. Better understanding of the …

The COVID-19 pandemic has precipitated a search for both effective treatments and patient
factors that predict poor outcome. Although agents ranging from convalescent plasma to …

Background The risk of severe COVID-19 outcomes in people with immune-mediated
inflammatory diseases and on immune-modifying drugs might not be fully mediated by …

As of March 12, 2020, coronavirus disease 2019 (COVID-19) has been con firmed in 125
048 people worldwide, carrying a mortality of approximately 3· 7%, 1 compared with a …

At the beginning of the COVID-19 pandemic, patients with immune-mediated inflammatory
diseases were considered to be at high risk for SARS-CoV-2 infection and the development …

Therapeutic approaches to mitigate the severe acute lung injury associated with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have rapidly entered …