Pseudomonas aeruginosa Gene Products PilT and PilU Are Required for Cytotoxicity In Vitro and Virulence in a Mouse Model of Acute Pneumonia

JC Comolli, AR Hauser, L Waite… - Infection and …, 1999 - Am Soc Microbiol
Type IV pili of the opportunistic pathogen Pseudomonas aeruginosa mediate twitching
motility and act as receptors for bacteriophage infection. They are also important bacterial …

Role of Pseudomonas aeruginosa pili in acute pulmonary infection

H Tang, M Kays, A Prince - Infection and immunity, 1995 - Am Soc Microbiol
The role of piliation in the development and course of acute pulmonary infection was
examined using infant BALB/cByJ mice inoculated by intranasal instillation of isogenic Pil+ …

Alteration of the pilin adhesin of Pseudomonas aeruginosa PAO results in normal pilus biogenesis but a loss of adherence to human pneumocyte cells and decreased …

MA Farinha, BD Conway, LM Glasier… - Infection and …, 1994 - Am Soc Microbiol
The disulfide loop domain of Pseudomonas aeruginosa PAO pilin was altered by insertion of
a chloramphenicol acetyltransferase gene into the pilin gene so that the C-terminal nine …

Twitching Motility Contributes to the Role of Pili in Corneal Infection Caused by Pseudomonas aeruginosa

I Zolfaghar, DJ Evans, SMJ Fleiszig - Infection and immunity, 2003 - Am Soc Microbiol
Twitching motility is a form of surface-associated bacterial movement mediated by type IV pili
of Pseudomonas aeruginosa. Others have shown that pilT and pilU mutants, which are …

Influence of Pilin Glycosylation on Pseudomonas aeruginosa 1244 Pilus Function

JG Smedley III, E Jewell, J Roguskie… - Infection and …, 2005 - Am Soc Microbiol
The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of nosocomial
pneumonia. Among its virulence factors, the type IV pili of P. aeruginosa strain 1244 contain …

Characterization of pilQ, a new gene required for the biogenesis of type 4 fimbriae in Pseudomonas aeruginosa

PR Martin, M Hobbs, PD Free, Y Jeske… - Molecular …, 1993 - Wiley Online Library
Type 4 fimbriae are produced by a variety of pathogens, in which they appear to function in
adhesion to epithelial cells, and in a form of surface translocation called twitching motility …

Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus‐associated adhesin

RW Heiniger, HC Winther‐Larsen… - Cellular …, 2010 - Wiley Online Library
Tissue damage predisposes humans to life‐threatening disseminating infection by the
opportunistic pathogen Pseudomonas aeruginosa. Bacterial adherence to host tissue is a …

Disparate Subcellular Localization Patterns of Pseudomonas aeruginosa Type IV Pilus ATPases Involved in Twitching Motility

P Chiang, M Habash, LL Burrows - Journal of bacteriology, 2005 - Am Soc Microbiol
The opportunistic pathogen Pseudomonas aeruginosa expresses polar type IV pili (TFP),
which are responsible for adhesion to various materials and twitching motility on surfaces …

The type-4 pilus is the major virulence-associated adhesin of Pseudomonas aeruginosa–a review

HP Hahn - Gene, 1997 - Elsevier
Pseudomonas aeruginosa (Pa) produces several surface-associated adherence factors or
adhesins which promote attachment to epithelial cells and contribute to the virulence of this …

Pseudomonas aeruginosa minor pilins are incorporated into type IV pili

CL Giltner, M Habash, LL Burrows - Journal of molecular biology, 2010 - Elsevier
Type IV pili are long filamentous appendages required for both adhesion and a unique form
of motility known as twitching. Twitching motility involves the extension and retraction of the …