Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …

Increasing evidence indicates that changes in the redox system may contribute to the
pathogenesis of multiple optic neuropathies. Optic neuropathies are characterized by the …

Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most
common neurodegenerative disorder that causes irreversible blindness worldwide. It is …

Glaucoma is a neurodegenerative disease of the eye and it is one of the leading causes of
blindness. Glaucoma is characterized by progressive degeneration of retinal ganglion cells …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. Although ROS are essential participants in cell signaling and …

Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

For many years, oxidative stress arising from the ubiquitous production of reactive oxygen
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …

Mitochondrial dysfunction increases reactive oxygen species (ROS) production and when
this overwhelms the cellular antioxidant defences, oxidative stress ensues. Oxidative stress …

Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and
antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell …

The significance of oxidative stress in the development of chronic neurodegenerative
diseases of the retina has become increasingly apparent in recent years. Reactive oxygen …