Innate or adaptive immunity? The example of natural killer cells

E Vivier, DH Raulet, A Moretta, MA Caligiuri, L Zitvogel… - science, 2011 - science.org
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity
endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK …

Killer cell immunoglobulin‐like receptors on NK cells: the how, where and why

CM Gardiner - International journal of immunogenetics, 2008 - Wiley Online Library
Natural killer (NK) cells have killer cell immunoglobulin‐like receptors (KIR) that recognize
and interact with HLA class I antigen. The KIRs are a multigene family and its members are …

Role of human natural killer cells in health and disease

TL Whiteside, RB Herberman - Clinical Diagnostic Laboratory …, 1994 - Am Soc Microbiol
Natural killer (NK) cells, the CD3-CD56+ CD16+ subset of peripheral blood lymphocytes,
have long been known to be involved in non-major histocompatibility complex-restricted …

Killer immunoglobulin-like receptors (KIRs) and HLA-C allorecognition patterns implicative of dominant activation of natural killer cells contribute to recurrent …

RM Faridi, S Agrawal - Human reproduction, 2011 - academic.oup.com
BACKGROUND Decidual natural killer (NK) cells play key developmental roles at the feto–
maternal interface. Individual differences in NK-cell interactions are dependent on the …

[HTML][HTML] Hanging in the balance

AP Williams, AR Bateman… - Molecular …, 2005 - triggered.edina.clockss.org
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of
activating and inhibitory receptors that control natural killer (NK) cell function. KIR exist as a …

Taking license with natural killer cell maturation and repertoire development

P Parham - Immunological reviews, 2006 - Wiley Online Library
Combining population analysis with in‐depth analysis of selected individuals, the tolerance
of human natural killer (NK) cells to autologous major histocompatibility complex (MHC) …

Developmental and functional control of natural killer cells by cytokines

Y Wu, Z Tian, H Wei - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

Diversification and functional specialization of human NK cell subsets

F Cichocki, H Schlums, J Theorell, B Tesi, JS Miller… - Natural Killer …, 2016 - Springer
Natural killer (NK) cells are lymphocytes that participate in different facets of immunity. They
can act as innate sentinels through recognition and eradication of infected or transformed …

The biology of natural killer cells and implications for therapy of human disease

EG Chiorean, JS Miller - Journal of hematotherapy & stem cell …, 2001 - liebertpub.com
Natural killer (NK) cells are unique lymphocytes capable of lysing target cells without prior
immunization. NK cells activated with cytokines, like interleukin-2 (IL-2), have been used …

[HTML][HTML] Cell-extrinsic MHC class I molecule engagement augments human NK cell education programmed by cell-intrinsic MHC class I

JE Boudreau, XR Liu, Z Zhao, A Zhang, LD Shultz… - Immunity, 2016 - cell.com
The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by" self"
MHC class I molecules in a process called" education." In humans, interactions between …