Interleukin-6 perpetrator of the COVID-19 cytokine storm

J Shekhawat, K Gauba, S Gupta, P Purohit… - Indian Journal of Clinical …, 2021 - Springer
COVID-19 has emerged as a global pandemic. It is mainly manifested as pneumonia which
may deteriorate into severe respiratory failure. The major hallmark of the disease is the …

Cytokine storm induced by SARS-CoV-2

P Song, W Li, J Xie, Y Hou, C You - Clinica chimica acta, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by the virus designated as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread widely throughout the …

Overview of the pathogenesis of COVID‑19

C Li, Q He, H Qian, J Liu - … and Therapeutic Medicine, 2021 - spandidos-publications.com
At present, the pathogenesis of the novel coronavirus disease 2019 (COVID‑19) has not
been fully elucidated. Clinical and experimental findings from studies investigating COVID …

[PDF][PDF] Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy

P Conti, A Caraffa, CE Gallenga, R Ross… - J Biol Regul Homeost …, 2020 - researchgate.net
SARS-Cov-2 infection causes local and systemic inflammation mediated by pro-
inflammatory cytokines and COX-2 eicosanoid products with metabolic dysfunction and …

Hyperinflammation and immune response generation in COVID-19

KP Mishra, AK Singh, SB Singh - Neuroimmunomodulation, 2021 - karger.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes coronavirus
disease 2019 (COVID-19) pandemic has affected millions of people worldwide. The …

Macrophage responses associated with COVID-19: A pharmacological perspective

GW Booz, R Altara, AH Eid, Z Wehbe, S Fares… - European Journal of …, 2020 - Elsevier
COVID-19 has caused worldwide death and economic destruction. The pandemic is the
result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has …

Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions

R Noroozi, W Branicki, K Pyrc, PP Łabaj, E Pospiech… - Cytokine, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic in early 2020. The infection has been associated with a wide range of clinical …

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

M Abbasifard, H Khorramdelazad - Life sciences, 2020 - Elsevier
Abstract Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many
innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel …

Characterization of the inflammatory response to severe COVID-19 illness

OJ McElvaney, NL McEvoy, OF McElvaney… - American journal of …, 2020 - atsjournals.org
Rationale: Coronavirus disease (COVID-19) is a global threat to health. Its inflammatory
characteristics are incompletely understood. Objectives: To define the cytokine profile of …

A scoping review of the pathophysiology of COVID-19

PE Marik, J Iglesias, J Varon… - International journal of …, 2021 - journals.sagepub.com
COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-
19 is probably amongst the most complex of medical conditions known to medical science …