The role of type I interferon in the treatment of COVID‐19

F Sodeifian, M Nikfarjam, N Kian… - Journal of medical …, 2022 - Wiley Online Library
Although significant research has been done to find effective drugs against coronavirus
disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 …

Characterization of SARS-CoV-2 evasion: interferon pathway and therapeutic options

M Znaidia, C Demeret, S van der Werf, AV Komarova - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to …

[HTML][HTML] Molecular conservation and differential mutation on ORF3a gene in Indian SARS-CoV2 genomes

SS Hassan, PP Choudhury, P Basu, SS Jana - Genomics, 2020 - Elsevier
A global emergency due to the COVID-19 pandemic demands various studies related to
genes and genomes of the SARS-CoV2. Among other important proteins, the role of …

SARS-CoV-2 nucleocapsid protein interacts with RIG-I and represses RIG-mediated IFN-β production

K Chen, F Xiao, D Hu, W Ge, M Tian, W Wang, P Pan… - Viruses, 2020 - mdpi.com
SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health
worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus …

SARS-CoV-2 nucleocapsid protein targets RIG-I-like receptor pathways to inhibit the induction of interferon response

SJ Oh, OS Shin - Cells, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the coronavirus disease 2019 (COVID-19) that has resulted in the current pandemic. The …

Interplay between SARS-CoV-2 and the type I interferon response

M Sa Ribero, N Jouvenet, M Dreux, S Nisole - PLoS pathogens, 2020 - journals.plos.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …

Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection

C Chiale, TT Greene, EI Zuniga - Immunological Reviews, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …

Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets

Y Yang, F Ye, N Zhu, W Wang, Y Deng, Z Zhao… - Scientific reports, 2015 - nature.com
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel and highly
pathogenic human coronavirus and has quickly spread to other countries in the Middle East …

Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells

C Metz-Zumaran, C Kee, P Doldan, C Guo… - Journal of …, 2022 - Am Soc Microbiol
The coronavirus SARS-CoV-2 caused the COVID-19 global pandemic leading to 5.3 million
deaths worldwide as of December 2021. The human intestine was found to be a major viral …

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses

A Banerjee, N El-Sayes, P Budylowski, RA Jacob… - IScience, 2021 - cell.com
Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies
have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data …