Development and evaluation of a genetic risk score for obesity
Multi-locus profiles of genetic risk, so-called “genetic risk scores,” can be used to translate
discoveries from genome-wide association studies into tools for population health research …
discoveries from genome-wide association studies into tools for population health research …
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity
S Hägg, A Ganna, SW Van Der Laan… - Human molecular …, 2015 - academic.oup.com
To date, genome-wide association studies (GWASs) have identified> 100 loci with single
variants associated with body mass index (BMI). This approach may miss loci with high …
variants associated with body mass index (BMI). This approach may miss loci with high …
Polygenic risk predicts obesity in both white and black young adults
Objective To test transethnic replication of a genetic risk score for obesity in white and black
young adults using a national sample with longitudinal data. Design and Methods A …
young adults using a national sample with longitudinal data. Design and Methods A …
Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans
YD Salinas, L Wang, AT DeWan - BMC genetics, 2016 - Springer
Background Genome-wide association studies of obesity have typically assumed fixed
genetic effects across ethnicities, rarely attempting to thoroughly compare and contrast …
genetic effects across ethnicities, rarely attempting to thoroughly compare and contrast …
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
Objective: Several genome–wide association studies (GWAS) have demonstrated that
common genetic variants contribute to obesity. However, studies of this complex trait have …
common genetic variants contribute to obesity. However, studies of this complex trait have …
Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI
KS Vimaleswaran, I Tachmazidou… - Human molecular …, 2012 - academic.oup.com
Before the advent of genome-wide association studies (GWASs), hundreds of candidate
genes for obesity-susceptibility had been identified through a variety of approaches. We …
genes for obesity-susceptibility had been identified through a variety of approaches. We …
Obesity genomics: assessing the transferability of susceptibility loci across diverse populations
Y Lu, RJF Loos - Genome medicine, 2013 - Springer
The prevalence of obesity has nearly doubled worldwide over the past three decades, but
substantial differences exist between nations. Although these differences are partly due to …
substantial differences exist between nations. Although these differences are partly due to …
Developments in obesity genetics in the era of genome-wide association studies
Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …
Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity
Obesity is a major public health problem with strong genetic determination. Multiple genetic
variants have been implicated for obesity by conducting genome-wide association (GWA) …
variants have been implicated for obesity by conducting genome-wide association (GWA) …
The role of obesity‐associated loci identified in genome‐wide association studies in the determination of pediatric BMI
The prevalence of obesity in children and adults in the United States has increased
dramatically over the past decade. Besides environmental factors, genetic factors are known …
dramatically over the past decade. Besides environmental factors, genetic factors are known …