Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept

EE Winger, JL Reed, X Ji, K Nicolaides - PLoS One, 2018 - journals.plos.org
Objective We investigated the capacity of microRNAs isolated from peripheral blood buffy
coat collected late during the first trimester to predict preeclampsia. Study design The cohort …

First trimester PBMC microRNA predicts adverse pregnancy outcome

EE Winger, JL Reed, X Ji - American journal of reproductive …, 2014 - Wiley Online Library
Problem Prior to the end of the first trimester, pathogenic mechanisms may commit
pregnancies to adverse outcome such as pre‐eclampsia and miscarriage. A long‐term …

Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy

A Luque, A Farwati, F Crovetto, F Crispi, F Figueras… - Scientific reports, 2014 - nature.com
To assess the usefulness of circulating microRNAs (miRNAs) as non-invasive molecular
biomarkers for early prediction of preeclampsia, a differential miRNA profiling analysis was …

Early first trimester peripheral blood cell microRNA predicts risk of preterm delivery in pregnant women: Proof of concept

EE Winger, JL Reed, X Ji - PLoS One, 2017 - journals.plos.org
Objective We investigated the capacity of first trimester peripheral blood mononuclear cell
(PBMC) microRNA to determine risk of spontaneous preterm birth among pregnant women …

Circulating microRNAs as biomarkers for diagnosis and prediction of preeclampsia: A systematic review and meta-analysis

Y Yin, M Liu, H Yu, J Zhang, R Zhou - European Journal of Obstetrics & …, 2020 - Elsevier
Objective We carried out a meta-analysis to quantitatively summarize the overall diagnostic
and predictive effects of circulating microRNAs in diagnosis and prediction of preeclampsia …

High-throughput deep screening and identification of four peripheral leucocyte microRNAs as novel potential combination biomarkers for preeclampsia

Y Wang, X Yang, Y Yang, W Wang, M Zhao… - Journal of …, 2016 - nature.com
Objective: To identify the specific microRNA (miRNA) biomarkers of preeclampsia (PE), the
miRNA profiles analysis were performed. Study Design: The blood samples were obtained …

MicroRNAs isolated from peripheral blood in the first trimester predict spontaneous preterm birth

EE Winger, JL Reed, X Ji, N Gomez-Lopez, P Pacora… - PLoS …, 2020 - journals.plos.org
Objective To predict spontaneous preterm birth among pregnant women in an African
American population using first trimester peripheral blood maternal immune cell microRNA …

Expression profiles of candidate microRNAs in the peripheral blood leukocytes of patients with early-and late-onset preeclampsia versus normal pregnancies

S Demirer, M Hocaoglu, A Turgut, A Karateke… - Pregnancy …, 2020 - Elsevier
Objectives Maternal leucocytes play an important role in the pathogenesis of preeclampsia
(PE). Circulating microRNAs (miRNAs) are small, noncoding RNA molecules. The purpose …

First trimester circulating miR-194-5p and miR-1278 improve prediction of preeclampsia

AA Clément, C Légaré, V Desgagné, K Thibeault… - Pregnancy …, 2023 - Elsevier
Objectives To identify first trimester circulating microRNAs associated with preeclampsia
(PE) and assess their predictive value in two independent cohorts Methods Circulating …

First-trimester maternal cell microRNA is a superior pregnancy marker to immunological testing for predicting adverse pregnancy outcome

EE Winger, JL Reed, X Ji - Journal of reproductive immunology, 2015 - Elsevier
Patients at risk of immune-mediated pregnancy complications have historically relied on the
use of peripheral blood immunological assays for diagnosis and pregnancy monitoring …