Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse
G Manassero, IE Repetto, S Cobianchi… - Molecular …, 2012 - journals.sagepub.com
Background: Current tools for analgesia are often only partially successful, thus
investigations of new targets for pain therapy stimulate great interest. Consequent to …
investigations of new targets for pain therapy stimulate great interest. Consequent to …
c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity
H Doya, S Ohtori, M Fujitani, T Saito, K Hata… - Biochemical and …, 2005 - Elsevier
Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through
the actions of inflammatory mediators. Mitogen-activated protein kinase cascades participate …
the actions of inflammatory mediators. Mitogen-activated protein kinase cascades participate …
A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons …
ZY Zhuang, YR Wen, DR Zhang, T Borsello… - Journal of …, 2006 - Soc Neuroscience
Optimal management of neuropathic pain is a major clinical challenge. We investigated the
involvement of c-Jun N-terminal kinase (JNK) in neuropathic pain produced by spinal nerve …
involvement of c-Jun N-terminal kinase (JNK) in neuropathic pain produced by spinal nerve …
Phosphorylation of c-Jun N-terminal kinase isoforms and their different roles in spinal cord dorsal horn and primary somatosensory cortex
MG Liu, FK Zhang, SW Guo, LF Zhao, YY An, XY Cui… - Neuroscience …, 2007 - Elsevier
The present study was undertaken to investigate whether isoforms of c-Jun N-terminal
kinase (JNK 46kDa and 54kDa), one component of the mitogen-activated protein kinase …
kinase (JNK 46kDa and 54kDa), one component of the mitogen-activated protein kinase …
Activation of JNK pathway in persistent pain
The c-Jun N-terminal kinase (JNK) is a stress-activated member of MAP kinase family. JNK
activation has been strongly implicated in inflammatory responses, neurodegeneration, and …
activation has been strongly implicated in inflammatory responses, neurodegeneration, and …
Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn
JIL Choi, FJ Koehrn, LS Sorkin - Molecular pain, 2012 - journals.sagepub.com
Background: Paw carrageenan induces activation of phosphatidylinositol 3-kinase (PI-3K)
and Akt in dorsal horn neurons in addition to induction of pain behavior. Spinal PI-3K …
and Akt in dorsal horn neurons in addition to induction of pain behavior. Spinal PI-3K …
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition
KT Kahle, JF Schmouth, V Lavastre, A Latremoliere… - Science …, 2016 - science.org
HSN2 is a nervous system predominant exon of the gene encoding the kinase WNK1 and is
mutated in an autosomal recessive, inherited form of congenital pain insensitivity. The HSN2 …
mutated in an autosomal recessive, inherited form of congenital pain insensitivity. The HSN2 …
Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model
Cancer pain significantly affects the quality of cancer patients, and current treatments for this
pain are limited. C-Jun N-terminal kinase (JNK) has been implicated in tumor growth and …
pain are limited. C-Jun N-terminal kinase (JNK) has been implicated in tumor growth and …
Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord
C Torsney, AB MacDermott - Journal of Neuroscience, 2006 - Soc Neuroscience
Blockade of local spinal cord inhibition mimics the behavioral hypersensitivity that manifests
in chronic pain states. This suggests that there is a pathway capable of mediating …
in chronic pain states. This suggests that there is a pathway capable of mediating …
Cell signaling and the genesis of neuropathic pain
RR Ji, G Strichartz - Science's STKE, 2004 - science.org
Damage to the nervous system can cause neuropathic pain, which is in general poorly
treated and involves mechanisms that are incompletely known. Currently available animal …
treated and involves mechanisms that are incompletely known. Currently available animal …