The Sry-containing protein Sox2 initially was known to regulate the self-renewal of the
mouse and human embryonic stem cells (ESCs). It is also important for the maintenance of …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …

The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

Transcriptional and epigenetic embryonic programs can be reactivated in cancer cells. As
result, a specific subset of undifferentiated cells with stem‐cells properties emerges and …

Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

The pluripotency-associated transcription factor SOX2 is essential during mammalian
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …

Background SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is
overexpressed in some solid tumors, and is expressed in epithelial cells of the lung …

Sox2 is a key transcription factor for embryonic development and plays a critical role in
determining the fate of stem cells. Recently, Sox2 has been detected in several human …

SOX2 is a stem cell transcription factor that plays a crucial role in the regulation of embryonic
development. It is one of the genes in a set of factors (Oct4, SOX2, Nanog) that are able to …