Abstract The cytochrome P450 3A (CYP3A) enzymes have a major role in the metabolism of
drugs in humans. Their wide substrate specificity and induction by a vast array of structurally …

Cytochrome P450 (CYP) enzymes function to catalyze a wide range of reactions, many of
which are critically important for drug response. Members of the human cytochrome P450 3A …

To gain a better understanding of the active site of cytochrome P-450 (CYP) 3A4, a three-
dimensional-quantitative structure activity relationship model was constructed using the …

Structure activity relationships (SAR), three-dimensional structure activity relationships (3D-
QSAR), and pharmacophores represent useful tools in understanding cytochrome P450 …

Human cytochrome P450 1A2 (CYP1A2) is one of the major CYPs in the liver (&sim13%)
and metabolizes about 20% of clinically used drugs. CYP1A2 is a 515-residue protein with a …

Without a crystallized structure for a human cytochrome P450, the use of computational
molecular modeling is one approach to examine the active site requirements of substrate …

Human microsomal cytochrome P450s participate in drug metabolism and detoxification.
Among them, CYP3A4 is the most important isoform for drug–drug interactions. To gain a …

Abstract Cytochrome P450 (CYP) family 1, 2, and 3 enzymes play an essential role in the
metabolic clearance and detoxification of a myriad of structurally and chemically diverse …

Cytochrome P450 (CYP) 1A1 is an extrahepatic monooxygenase involved in the metabolism
of endogenous substrates and drugs, as well as the activation of certain toxins and …

Human cytochrome P450 (CYP) 3A4 is the most abundant hepatic and intestinal phase I
enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound …