Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

TF Rogers, F Zhao, D Huang, N Beutler, A Burns, W He… - Science, 2020 - science.org
Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global
health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 …

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

PJM Brouwer, TG Caniels, K van der Straten… - Science, 2020 - science.org
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
had a large impact on global health, travel, and economy. Therefore, preventative and …

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

D Li, RJ Edwards, K Manne, DR Martinez, A Schäfer… - BioRxiv, 2021 - biorxiv.org
Summary SARS-CoV-2 neutralizing antibodies (NAbs) protect against COVID-19, making
them a focus of vaccine design. A safety concern regarding SARS-CoV-2 antibodies is …

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen… - BioRxiv, 2020 - biorxiv.org
The COVID-19 pandemic is a major threat to global health for which there are only limited
medical countermeasures, and we lack a thorough understanding of mechanisms of …

Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern

AA Gorchakov, SV Kulemzin, SV Guselnikov… - Cell Discovery, 2021 - nature.com
In the absence of virus-targeting small-molecule drugs approved for the treatment and
prevention of COVID-19, broadening the repertoire of potent SARS-CoV-2-neutralizing …

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

D Li, RJ Edwards, K Manne, DR Martinez, A Schäfer… - Cell, 2021 - cell.com
Summary SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern
regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we …

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

KM Hastie, H Li, D Bedinger, SL Schendel… - Science, 2021 - science.org
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses

M Mandolesi, DJ Sheward, L Hanke, J Ma… - Cell Reports …, 2021 - cell.com
The outbreak and spread of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-
2) is a current global health emergency, and effective prophylactic vaccines are needed …

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

L Liu, P Wang, MS Nair, J Yu, M Rapp, Q Wang, Y Luo… - Nature, 2020 - nature.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic continues,
with devasting consequences for human lives and the global economy,. The discovery and …

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

A Wajnberg, F Amanat, A Firpo, DR Altman, MJ Bailey… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic with millions infected and more than 1 million fatalities. Questions regarding the …