Human organ-on-a-chip models are powerful tools for preclinical research that can be used
to study the mechanisms of disease and evaluate new targets for therapeutic intervention …

Lung diseases have become a significant challenge to public healthcare worldwide, which
stresses the necessity of developing effective biological models for pathophysiological and …

The convergence of cell biology with microfabrication technology derived from the
microelectronics industry has made it possible to engineer physiologically relevant and …

The lung is a complex organ comprising a branched airway that connects the large airway
and millions of terminal gas-exchange units. Traditional pulmonary biomedical research by …

The lung is the primary respiratory organ of the human body and has a complicated and
precise tissue structure. It comprises conductive airways formed by the trachea, bronchi and …

Tissue engineering approaches, including those to functional lung tissues, are finely honed
by the inclusion of upgraded devices that mimic biophysical and biochemical features in …

Much of our understanding of lung pathophysiology has been gained from traditional in vitro
and in vivo animal assays, but they are inadequate for investigating fundamental disease …

Abstract Recently, organ-on-a-chip models, which are microfluidic devices that mimic the
cellular architecture and physiological environment of an organ, have been developed and …

Pathologies of the respiratory system such as lung infections, chronic inflammatory lung
diseases, and lung cancer are among the leading causes of morbidity and mortality, killing …

Development of organoids and microfluidic on-chip models has enabled studies of organ-
level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are …