Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection

E De Clercq - Il Farmaco, 1999 - Elsevier
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have, in addition to the nucleoside
reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), gained a definitive …

The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection

E De Clercq - Antiviral research, 1998 - Elsevier
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have, in addition to the nucleoside
reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), gained a definitive …

Non‐nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future

E De Clercq - Chemistry & biodiversity, 2004 - Wiley Online Library
Non‐nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent
ingredient of the drug combination schemes that are currently used in the treatment of …

Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives

G Campiani, A Ramunno, G Maga… - Current …, 2002 - ingentaconnect.com
Along with nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),
nonnucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive and …

Looking for an active conformation of the future HIV type-1 non-nucleoside reverse transcriptase inhibitors

GL Regina, A Coluccia… - Antiviral Chemistry and …, 2010 - journals.sagepub.com
HIV type-1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key drugs
of highly active antiretroviral therapy (HAART) in the clinical management of AIDS/HIV …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989 …

MP de Béthune - Antiviral research, 2010 - Elsevier
It is almost 20 years since NNRTIs were identified as a new class of antiretroviral drugs for
the treatment of HIV-1 infection. Although they belong to different and diverse chemical …

Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment

Y Wang, E De Clercq, G Li - Expert opinion on drug metabolism & …, 2019 - Taylor & Francis
Introduction: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are essential
components of highly active antiretroviral therapy against HIV-1 infections. Here, we provide …

Recent discoveries in HIV-1 reverse transcriptase inhibitors

SX Gu, YY Zhu, C Wang, HF Wang, GY Liu… - Current Opinion in …, 2020 - Elsevier
HIV-1 reverse transcriptase inhibitors (RTIs) are indispensable components of highly active
antiretroviral therapy (HAART), which has achieved great success in controlling AIDS …

[引用][C] Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV‐1) infections: strategies to overcome …

E De Clercq - Medicinal research reviews, 1996 - Wiley Online Library
The first compounds ever shown to specifically inhibit HIV-1 (human immunodeficiency virus
type l), but not HIV-2 (human immunodeficiency virus type 2), replication were the 1-(2 …

Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of seven representative paradigms

D Li, P Zhan, E De Clercq, X Liu - Journal of medicinal chemistry, 2012 - ACS Publications
Currently, five NNRTIs have been approved by US Food and Drug Administration (US FDA)
for the clinical treatment of AIDS, ie, nevirapine, delavirdine, efavirenz, etravirine, and …