Background: The KCa3. 1 channel is the intermediate-conductance member of the Ca2+-
activated K channel superfamily. It is widely expressed in excitable and non-excitable cells …

Abstract Ca2+-activated K+ (KCa) channels of small (SK) and intermediate (IK) conductance
are present in a wide range of excitable and non-excitable cells. On activation by low …

Abstract Ca2+‐activated K+ (KCa) channels play a pivotal role in the physiology of a wide
variety of tissues and disease states, including vascular endothelia, secretory epithelia …

The Ca2+-activated potassium channel of intermediate conductance, KCa3. 1, is now
emerging as a therapeutic target for a large variety of health disorders. The Ca2+ sensitivity …

The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high
external and low internal concentration. Many Ca2+-sensing ion channel proteins have …

In this study we present evidence that residue Val 282 in the S6 transmembrane segment of
the calcium-activated KCa3. 1 channel constitutes a key determinant of channel gating. A …

Potassium channels belong to the largest and the most diverse super-families of ion
channels. Among them, Ca 2+-activated K+ channels (KCa) comprise many members …

This short review discusses pharmacological modulation of the opening/closing properties
(gating) of small-and intermediate-conductance Ca2+-activated K+ channels (KCa2 and …

Three genes encode the small‐conductance Ca2+‐activated K+ channels (SK channels).
We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed the …

Large-conductance Ca2+-activated K+ (BK-Ca) channels differ from most of other K+
channels in that their activation is under dual control, ie, activated by either increase in …