Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis

LE Gralinski, TP Sheahan, TE Morrison, VD Menachery… - MBio, 2018 - Am Soc Microbiol
Acute respiratory distress syndrome (ARDS) is immune-driven pathologies that are
observed in severe cases of severe acute respiratory syndrome coronavirus (SARS-CoV) …

Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice

WG Glass, K Subbarao, B Murphy… - The Journal of …, 2004 - journals.aai.org
We describe a model of severe acute respiratory syndrome-coronavirus (SARS-CoV)
infection in C57BL/6 mice. A clinical isolate of the virus introduced intranasally replicated …

Severe acute respiratory syndrome and the innate immune responses: modulation of effector cell function without productive infection

CTK Tseng, LA Perrone, H Zhu, S Makino… - The Journal of …, 2005 - journals.aai.org
Severe acute respiratory syndrome (SARS) caused by a novel human coronavirus (CoV),
designated SARS-CoV, is a highly contagious respiratory disease with the lungs as a major …

T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice

J Zhao, J Zhao, S Perlman - Journal of virology, 2010 - Am Soc Microbiol
ABSTRACT A dysregulated innate immune response and exuberant cytokine/chemokine
expression are believed to be critical factors in the pathogenesis of severe acute respiratory …

Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro

YT Yen, F Liao, CH Hsiao, CL Kao, YC Chen… - Journal of …, 2006 - Am Soc Microbiol
The clinical picture of severe acute respiratory syndrome (SARS) is characterized by
pulmonary inflammation and respiratory failure, resembling that of acute respiratory distress …

Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells

M Spiegel, K Schneider, F Weber… - Journal of general …, 2006 - microbiologyresearch.org
Severe acute respiratory syndrome (SARS) of humans is caused by a novel coronavirus of
zoonotic origin termed SARS-associated coronavirus (SARS-CoV). The virus induces …

Severe acute respiratory syndrome coronavirus 2–induced immune activation and death of monocyte-derived human macrophages and dendritic cells

J Zheng, Y Wang, K Li, DK Meyerholz… - The Journal of …, 2021 - academic.oup.com
Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
patients and experimentally infected animals indicate a critical role for augmented …

Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells

HKW Law, CY Cheung, HY Ng, SF Sia, YO Chan… - Blood, 2005 - ashpublications.org
Lymphopenia and increasing viral load in the first 10 days of severe acute respiratory
syndrome (SARS) suggested immune evasion by SARS-coronavirus (CoV). In this study, we …

Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival

ML DeDiego, JL Nieto-Torres, JA Regla-Nava… - Journal of …, 2014 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a
respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV …

Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis

CY Cheung, LLM Poon, IHY Ng, W Luk, SF Sia… - Journal of …, 2005 - Am Soc Microbiol
The pathogenesis of severe acute respiratory syndrome (SARS) remains unclear.
Macrophages are key sentinel cells in the respiratory system, and it is therefore relevant to …