Chronic inflammation is associated with aging and plays a causative role in several age-
related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …

Aging and cancer are clearly associated processes, at both the epidemiological and
molecular level. Epigenetic mechanisms are good candidates to explain the molecular links …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Background Primary cells enter replicative senescence after a limited number of cell
divisions. This process needs to be considered in cell culture experiments, and it is …

Accumulation of senescent cells during aging contributes to chronic inflammation and age-
related diseases. While senescence is associated with profound alterations of the …

Ageing has been associated with structural changes in chromatin. At the molecular level,
multiple histone modifications with established epigenetic mechanisms have been …

Emerging evidence indicates that epigenetic regulators are critically required for the
maintenance of tissue-specific stem cells and that the epigenetic marks are altered in stem …

Cellular senescence is a state of permanent replicative arrest that allows cells to stay viable
and metabolically active but resistant to apoptotic and mitogenic stimuli. Specific, validated …