Resistance to β-lactam antibiotics mediated by metallo-β-lactamases is an increasingly
worrying clinical problem. Candidate inhibitors include mercaptocarboxylic acids, and we …

The resistance of bacteria to the normally lethal action of β-lactam antibiotics is largely due
to the production of β-lactamases that catalyze the hydrolysis of the β-lactam. One class of …

A series of mercaptophenylacetic acid thiol esters bearing a phenyl substituent adjacent to
the carboxylic acid function has been shown to be inhibitors of metallo-β-lactamases. The …

Thiomandelic acid is a simple, broad spectrum, and reasonably potent inhibitor of metallo-β-
lactamases, enzymes that mediate resistance to β-lactam antibiotics. We report studies by …

A series of mercaptoacetic acid thiol esters have been identified as metallo-beta-lactamase
inhibitors. Electrospray mass spectrometry (ESMS) has shown that irreversible inhibition of …

1. The Zn (II)-requiring beta-lactamase from Bacillus cereus 569/H/9, which has two zinc-
binding sites, was examined by 270 MHz 1H nmr spectroscopy. Resonances were assigned …

The mononuclear zinc thiolate complexes [(TpPhMe) Zn (SR)], where TpPhMe is hydrotris
((3-methyl-5-phenyl) pyrazolyl) borate and (SR) is benzyl thiolate, 4-nitrophenylthiolate, 4 …

As part of a structure-aided effort to design clinically useful inhibitors of metallo-β-
lactamases, the X-ray crystal structure of a complex between the metallo-β-lactamase from …

Formation of a tetrahedral intermediate by nucleophilic attack on the β-lactam carbonyl
carbon of penicillins generates a lone pair on the β-lactam nitrogen which is syn to the …

The 8-thioxocephalosporins are poor substrates for the B. cereus metallo β-lactamase
(kcat/Km= 61.4 M− 1 s− 1) and act as weak competitive inhibitors (Ki∼ 700 μM). The …