Although immunotherapies of tumors have demonstrated promise for altering the
progression of malignancies, immunotherapies have been limited by an …

Macrophage activation comprises a continuum of functional states critically determined by
cytokine microenvironment. Activated macrophages have been functionally grouped …

Over-expression of folate receptor alpha on cancer cells has been frequently exploited for
delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited …

The vitamin, folic acid, has become a useful ligand for targeted cancer therapies because it
binds to a tumor-associated antigen known as the folate receptor (FR). By linking folic acid to …

The cell surface receptor for the vitamin folic acid (termed the folate receptor), is often
elevated in cancers of the ovary, kidney, lung, mammary gland, brain, endometrium, and …

Over the last 25+ years, the folate receptor (FR) has emerged as an attractive tumor
biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence …

Recently various strategies have been developed to exploit in a clinical setting the well
established finding that T cells can specifically recognize and destroy tumor cells. Several …

For over a decade the folate receptor has been intensively investigated as a means for
tumor-specific delivery of a broad range of experimental therapies including several …

We previously exploited the frequent overexpression of folate receptors on cancer cells to
decorate malignant cell surfaces selectively with folate‐hapten conjugates. In antihapten …

T cells expressing a chimeric antigen receptor (CAR) can produce dramatic results in
lymphocytic leukemia patients; however, therapeutic strategies for myeloid leukemia remain …