The transcription factor EB (TFEB) is a master regulator of lysosome biogenesis and
autophagy, and its activity is primarily controlled by the kinase complex mTORC1. In the Birt …

TFE3 is an oncogenic transcription factor whose subcellular localization and activity are
regulated by post-translational modifications. TFE3 is hyper-phosphorylated in the …

Abstract Birt–Hogg–Dubé (BHD) syndrome is an inherited renal cancer syndrome in which
affected individuals are at risk of developing benign cutaneous fibrofolliculomas, bilateral …

Abstract Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome
characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and …

Germline mutations in the novel tumor suppressor gene FLCN are responsible for the
autosomal dominant inherited disorder Birt-Hogg-Dubé (BHD) syndrome that predisposes to …

Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant condition caused by
mutations in the FLCN gene and characterized by benign hair follicle tumors, pneumothorax …

Folliculin (FLCN) is a tumor suppressor gene responsible for the inherited Birt-Hogg-Dubé
(BHD) syndrome, which affects kidneys, skin and lungs. FLCN is a highly conserved protein …

Abstract Birt-Hogg-Dubé (BHD) syndrome patients are uniquely susceptible to all renal
tumour subtypes. The underlying mechanism of carcinogenesis is unclear. To study cancer …

FLCN was identified as the gene responsible for Birt-Hogg-Dubé (BHD) syndrome, a
hereditary syndrome associated with the appearance of familiar renal oncocytomas. Most …

Since the hallmark dermatologic features of Birt–Hogg–Dubé (BHD) syndrome were first
described by three Canadian physicians in 1977, the clinical manifestations of BHD have …