COVID‐19: Consider IL‐6 receptor antagonist for the therapy of cytokine storm syndrome in SARS‐CoV‐2 infected patients

C Chakraborty, AR Sharma… - Journal of medical …, 2020 - Wiley Online Library
COVID‐19 leads to mortality of several patients and the cytokine storm is reportedly critical
in the patients. To reduce the cytokine storm, we would like to propose the interleukin (IL) 6 …

[HTML][HTML] The role of Interleukin 6 inhibitors in therapy of severe COVID-19

E Nasonov, M Samsonov - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cytokine storm syndrome (CSS) is a severe complication of inflammatory immune diseases
or treatment of malignancies; it may also appear during the progression of COVID-19. CSS …

[HTML][HTML] Evaluation of infliximab/tocilizumab versus tocilizumab among COVID-19 patients with cytokine storm syndrome

NM Sarhan, AEA Warda, HSG Ibrahim, MF Schaalan… - Scientific Reports, 2023 - nature.com
Abstract Coronavirus Disease 2019 (COVID-19) continues to spread rapidly. Monoclonal
antibodies as well as anti-tumor necrosis factor are considered promising treatments for …

Tocilizumab challenge: A series of cytokine storm therapy experiences in hospitalized COVID‐19 pneumonia patients

B Borku Uysal, H Ikitimur, S Yavuzer… - Journal of medical …, 2020 - Wiley Online Library
To recognize the period of exaggerated cytokine response in patients with coronavirus
disease 2019 (COVID‐19) pneumonia, and to describe the clinical outcomes of using …

Tocilizumab: a therapeutic option for the treatment of cytokine storm syndrome in COVID-19

A Saha, AR Sharma, M Bhattacharya, G Sharma… - Archives of medical …, 2020 - Elsevier
Presently, we need more therapeutic molecules for this COVID-19 outbreak. The severity
and mortality of the disease is associated with a high level of release of cytokine in the …

[PDF][PDF] Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

LYC Chen, CM Biggs, S Jamal, S Stukas… - Cell Reports …, 2021 - cell.com
Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet
IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble …

[HTML][HTML] Role of IL-6 inhibitor in treatment of COVID-19-related cytokine release syndrome

P Du, J Geng, F Wang, X Chen, Z Huang… - International journal of …, 2021 - ncbi.nlm.nih.gov
Cytokine release syndrome (CRS) may be the key factor in the pathology of severe
coronavirus disease 2019 (COVID-19). As a major driver in triggering CRS in patients with …

[HTML][HTML] COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This …

Clinical outcomes in COVID‐19 patients treated with tocilizumab: an individual patient data systematic review

D Antwi‐Amoabeng, Z Kanji, B Ford… - Journal of medical …, 2020 - Wiley Online Library
Background Current evidence suggests an important role of the interleukin‐6 (IL‐6) pathway
in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐related cytokine …

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19),
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …