The excision of introns from nuclear mRNA precursors (pre-mRNA) is a fundamental step in
the biogenesis of most mRNAs in eukaryotic cells and occurs prior to the transport of newly …

The biogenesis of mature, functional mRNA in eukaryotes often requires the precise
excision of noncoding, intervening sequences (ie, introns) which are present in the …

The primary transcripts of most nuclear protein-coding genes of eu-karyotes are interrupted
by intervening sequences (or introns) that are removed from the pre-mRNA in a process …

A characteristic feature of eukaryotic cells is that the primary transcription products of their
structural genes (pre-mRNAs) undergo a variety of post transcriptional modifications to …

Publisher Summary This chapter discusses the organization of RNA splicing in the cell
nucleus. Messenger RNA (mRNA) is transcribed from nuclear chromosomal DNA as large …

In eukaryotic cells most primary transcripts of protein-coding genes are processed through a
variety of post-transcriptional modification reactions to yield mature mRNA. One of these …

Seven years have elapsed since the development of in vitro systems that efficiently splice
exogenously added pre-mRNA substrates (Hernandez & Keller 1983; Krainer et al 1984; Lin …

Most messenger RNAs in higher eukaryotes are transcribed as precursors containing
intervening sequences (introns). Introns are removed by a sophisticated processing …

The process of pre-mRNA splicing is fundamental to gene regulation in eukaryotes. Specific
RNA sequences called introns, which do not code for amino acids, are removed during …

Nascent transcripts are the true substrates for many splicing events in mammalian cells. In
this review we discuss transcription, splicing, and alternative splicing in the context of co …