Sequence-specific transcription factors (TFs) are important to genetic regulation in all
organisms because they recognize and directly bind to regulatory regions on DNA. Here, we …

Transcription factors (TFs) play key roles in the regulation of gene expression by binding in a
sequence-specific manner to genomic DNA. In eukaryotes, DNA binding is achieved by a …

Coordinated regulation of gene expression relies on transcription factors (TFs) binding to
specific DNA sites. Our large-scale information–theoretical analysis of> 950 TF-binding …

DNA-binding domains (DBDs) are essential components of sequence-specific transcription
factors (TFs). We have investigated the distribution of all known DBDs in more than 500 …

Motivation: Traditional and high-throughput techniques for determining transcription factor
(TF) binding specificities are generating large volumes of data of uneven quality, which are …

Gene regulation at the transcriptional level is a central process in all organisms, and DNA-
binding transcription factors, known as TFs, play a fundamental role. This class of proteins …

Assignment of all transcription factors (TFs) from genome sequence data is not a
straightforward task due to the wide variation in TFs among different species. A DNA binding …

Transcription factors (TFs) have a central role in genome regulation directing gene
transcription through binding specific DNA sequences. Eukaryotic genomes encode a large …

Variations in noncoding regulatory sequences play a central role in evolution. Interpreting
such variations, however, remains difficult even in the context of defined attributes such as …

To understand the evolutionary dynamics between transcription factor (TF) binding and
gene expression in mammals, we compared transcriptional output and the binding …