The kidney is widely used to study the mechanisms of organogenesis. Its development
involves fundamental processes, such as epithelial branching, induced morphogenesis and …

Although it is not easy to investigate the regulatory basis of developmental processes in
most mammalian tissues, the mouse kidney has several distinct advantages as a model …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

Abnormalities of kidney and urinary tract development are the most common cause of end-
stage kidney failure in childhood in the United States. Over the past 20 years, the advent of …

As in most organs, the emerging theme in kidney development is the importance of cross-
talk between several tissues and cell lineages to allow morphogenesis to proceed in a …

Kidney development is based on differential cell-type-specific expression of a vast number
of genes. While multiple critical genes and pathways have been elucidated, a genome-wide …

The mechanisms underlying kidney development in mice and humans is an area of intense
study. Insights into kidney organogenesis have the potential to guide our understanding of …

In recent years, gene inactivation in the mouse and other model systems has shed new light
on the processes of inductive tissue interactions and morphogenesis. These studies have …

The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …

The development of the mammalian kidney is well conserved from mouse to man. Despite
considerable temporal and spatial data on gene expression in mammalian kidney …