Aging is a multifactorial process that involves changes at the cellular, tissue, organ and the
whole body levels resulting in decreased functioning, development of diseases, and …

Methylglyoxal (MG) is a reactive dicarbonyl intermediate of the glycolytic pathway. Increased
oxidative stress is associated with conditions of increased MG, such as diabetes mellitus …

Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major
hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Glucose and fructose metabolism originates the highly reactive byproduct methylglyoxal
(MG), which is a strong precursor of advanced glycation end products (AGE). The MG has …

Methylglyoxal (MG) is a highly reactive aldehyde spontaneously formed in human cells
mainly as a by-product of glycolysis. Such endogenous metabolite reacts with proteins …

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose
metabolism. This metabolite has been implicated in diabetic complications as it is a strong …

Advanced glycation end products (AGEs) are found in various intraneuronal protein deposits
such as neurofibrillary tangles in Alzheimer's disease and Lewy bodies in Parkinson's …