[PDF][PDF] A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies

AO Hassan, JB Case, ES Winkler, LB Thackray… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
with millions of human infections. One limitation to the evaluation of potential therapies and …

[PDF][PDF] A mouse model of SARS-CoV-2 infection and pathogenesis

SH Sun, Q Chen, HJ Gu, G Yang, YX Wang… - Cell host & …, 2020 - cell.com
Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread
throughout the world, resulting in a global public health emergency. The lack of vaccine and …

Cell and animal models of SARS-CoV-2 pathogenesis and immunity

SR Leist, A Schäfer… - Disease models & …, 2020 - journals.biologists.com
The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases
first identified in December 2019, and> 22 million people infected and> 775,000 deaths as …

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

ES Winkler, AL Bailey, NM Kafai, S Nair… - Nature …, 2020 - nature.com
Although animal models have been evaluated for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …

[PDF][PDF] Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment

J Sun, Z Zhuang, J Zheng, K Li, RLY Wong, D Liu… - Cell, 2020 - cell.com
Summary COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with> 4,000,000
confirmed cases worldwide and> 290,000 deaths as of May 15, 2020. It is critical that …

Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

A Muruato, MN Vu, BA Johnson, ME Davis-Gardner… - PLoS …, 2021 - journals.plos.org
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has
resulted in a pandemic causing significant damage to public health and the economy. Efforts …

COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice

C Lutz, L Maher, C Lee, W Kang - Human Genomics, 2020 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a declared pandemic that is spreading all
over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 …

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice

FS Oladunni, JG Park, PA Pino, O Gonzalez… - Nature …, 2020 - nature.com
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease
would benefit from validated small animal models. Here, we show that transgenic mice …

SARS-CoV-2 causes lung infection without severe disease in human ACE2 knock-in mice

ES Winkler, RE Chen, F Alam, S Yildiz, JB Case… - Journal of …, 2022 - Am Soc Microbiol
The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection

R Rathnasinghe, S Strohmeier, F Amanat… - Emerging microbes & …, 2020 - Taylor & Francis
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide
pandemic with high morbidity and mortality. Development of animal models that recapitulate …