Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

W Li, C Chen, A Drelich, DR Martinez… - Proceedings of the …, 2020 - National Acad Sciences
Effective therapies are urgently needed for the SARS-CoV-2/COVID-19 pandemic. We
identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed …

Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2

Y Higuchi, T Suzuki, T Arimori, N Ikemura… - Nature …, 2021 - nature.com
SARS-CoV-2 has mutated during the global pandemic leading to viral adaptation to
medications and vaccinations. Here we describe an engineered human virus receptor …

[HTML][HTML] The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

L Bao, W Deng, B Huang, H Gao, J Liu, L Ren, Q Wei… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus
disease 2019 (COVID-19), which has become a public health emergency of international …

SARS-CoV-2 infection in K18-ACE2 transgenic mice replicates human pulmonary disease in COVID-19

VM Arce, JA Costoya - Cellular & Molecular Immunology, 2021 - nature.com
Over the last several months, a global pandemic has developed due to the emergence of the
novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is capable of …

Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

SN Langel, S Johnson, CI Martinez… - Science Translational …, 2022 - science.org
Transmission-blocking strategies that slow the spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and protect against coronavirus disease 2019 (COVID-19) are …

Animal models for COVID-19: advances, gaps and perspectives

C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …

Experimental models of COVID-19

LA Caldera-Crespo, MJ Paidas, S Roy… - Frontiers in cellular …, 2022 - frontiersin.org
COVID-19 is the most consequential pandemic of the 21st century. Since the earliest stage
of the 2019-2020 epidemic, animal models have been useful in understanding the …

Establishment of an African green monkey model for COVID-19 and protection against re-infection

C Woolsey, V Borisevich, AN Prasad, KN Agans… - Nature …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an
unprecedented global pandemic of COVID-19. Animal models are urgently needed to study …

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

C Lei, K Qian, T Li, S Zhang, W Fu, M Ding… - Nature …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China,
at the end of 2019, and there are currently no specific antiviral treatments or vaccines …

Experimental models of SARS-CoV-2 infection: possible platforms to study COVID-19 pathogenesis and potential treatments

S Pandamooz, B Jurek, CP Meinung… - Annual review of …, 2022 - annualreviews.org
In December 2019, a novel coronavirus crossed species barriers to infect humans and was
effectively transmitted from person to person, leading to a worldwide pandemic …