A complex interplay of metabolic and immunological mechanisms underlies many diseases
that represent a substantial unmet medical need. There is an increasing appreciation of the …

Highlights•Engineered bacteria provide a continuous supply of therapeutic
molecules.•Bacterial therapies target inflammation, immunity, cancer, and metabolic …

There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

Microbes can be engineered to act like living therapeutics designed to perform specific
actions in the human body. From fighting and preventing infections to eliminating tumors and …

Synthetic cell therapy is a field that has broad potential for future applications in human
disease treatment. Next generation therapies will consist of engineered bacterial strains …

Bacteria are emerging as living drugs to treat a broad range of disease indications.
However, the inherent advantages of these replicating and immunostimulatory therapies …

Future advances in therapeutics demand the development of dynamic and intelligent living
materials. The past static monofunctional materials shall be unable to meet the requirements …

Recent advances in synthetic biology and biological system engineering have allowed the
design and construction of engineered live biotherapeutics targeting a range of human …

Synthetic biology aims to apply engineering principles to biology by modulating the behavior
of living organisms. An emerging application of this field is the engineering of bacteria as a …

Our ability to generate bacterial strains with unique and increasingly complex functions has
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …