Neural stem/progenitor cells capable of generating new neurons and glia, reside in specific
areas of the adult mammalian central nervous system (CNS), including the ependymal …

Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical
need for regenerative therapies apparent. Neural stem/progenitor cells (NSPCs) are …

Stem cell therapies have the potential to not only repair, but to regenerate tissue of the
central nervous system (CNS). Recent studies demonstrate that transplanted stem cells can …

Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

For many years, accepted dogma held that brain is a static organ with no possibility of
regeneration of cells in injured or diseased human brain. However, recent preclinical reports …

Central neurotrauma, such as spinal cord injury or traumatic brain injury, can damage critical
axonal pathways and neurons and lead to partial to complete loss of neural function that is …

Spinal cord injury (SCI) remains a life-altering event that devastates those injured and the
families that support them. Numerous laboratories are engaged in preclinical and clinical …

Tissue engineering using stem cells is widely used to repair damaged tissues in diverse
biological systems; however, this approach has met with less success in regenerating the …

Progress is being made in developing neuroprotective strategies for traumatic brain injuries;
however, there will never be a therapy that will fully preserve neurons that are injured from …

Traumatic brain injury (TBI) is a major cause of morbidity and mortality in the United States.
Current clinical therapy is focused on optimization of the acute/subacute intracerebral milieu …