Modeling interaction and dispersion effects in the analysis of gene-by-environment interaction

BW Domingue, K Kanopka, TT Mallard, S Trejo… - Behavior genetics, 2022 - Springer
Genotype-by-environment interaction (GxE) studies probe heterogeneity in response to risk
factors or interventions. Popular methods for estimation of GxE examine multiplicative …

Evaluation of uncontrolled confounding in studies of environmental exposures and neurobehavioral testing in children

PJ Mink, M Goodman, LM Barraj, H Imrey… - …, 2004 - journals.lww.com
Background: Neurobehavioral tests are commonly used in studies of children exposed to
low-level environmental concentrations of compounds known to be neurotoxic at higher …

Translational epidemiologic approaches to understanding the consequences of early-life exposures

BM D'Onofrio, QA Class, ME Rickert, AC Sujan… - Behavior genetics, 2016 - Springer
Prominent developmental theories posit a causal link between early-life exposures and later
functioning. Yet, observed associations with early exposures may not reflect causal effects …

[图书][B] Genetic effects on environmental vulnerability to disease

MJ Rutter - 2008 - books.google.com
Much research has attempted to show direct linear relations between genes and disorder.
However, scientists have been discouraged by inconsistent findings based on this simple …

Genetic influences on measures of the environment: a systematic review

KS Kendler, JH Baker - Psychological medicine, 2007 - cambridge.org
Background. Traditional models of psychiatric epidemiology often assume that the
relationship between individuals and their environment is unidirectional, from environment …

Editorial policy for candidate gene studies

C Johnston, BB Lahey, W Matthys - Journal of Abnormal Child Psychology, 2013 - Springer
The Journal of Abnormal Child Psychology receives an increasing number of manuscripts
reporting tests of associations of candidate genetic polymorphisms with measures of …

[HTML][HTML] Estimating the association between exposome and psychosis as well as general psychopathology: Results from the ABCD Study

LK Pries, TM Moore, E Visoki, I Sotelo… - … Psychiatry Global Open …, 2022 - Elsevier
Background The exposome comprises all nongenetic factors an individual is exposed to
across their lifespan. Research suggests that exposomic vulnerability for schizophrenia is …

The impact of gene-environment dependence and misclassification in genetic association studies incorporating gene-environment interactions

S Lindström, YC Yen, D Spiegelman, P Kraft - Human heredity, 2009 - karger.com
The possibility of gene-environment interaction can be exploited to identify genetic variants
associated with disease using a joint test of genetic main effect and gene-environment …

Psychosocial influences: Critiques, findings, and research needs

M Rutter - Development and psychopathology, 2000 - cambridge.org
Nongenetic factors have a major influence on psychopathology. Knowledge on specific
psychosocial risk and protective mechanisms is more limited because of inadequate …

Statistical approaches for investigating periods of susceptibility in children's environmental health research

JP Buckley, GB Hamra, JM Braun - Current environmental health reports, 2019 - Springer
Abstract Purpose of Review Children's environmental health researchers are increasingly
interested in identifying time intervals during which individuals are most susceptible to …