Targeted plasmalogen supplementation: Effects on blood plasmalogens, oxidative stress biomarkers, cognition, and mobility in cognitively impaired persons

DB Goodenowe, J Haroon, MA Kling… - Frontiers in cell and …, 2022 - frontiersin.org
Plasmalogens are a specific type of glycerophospholipid found in especially high levels in
neuronal membranes. Decreased blood and brain levels of docosahexaenoic acid (DHA) …

[HTML][HTML] Alkyl-acylglycerols and the important clinical ramifications of raising plasmalogens in dementia and Alzheimer's disease

CD Meletis - Integrative Medicine: A Clinician's Journal, 2020 - ncbi.nlm.nih.gov
A critical factor involved in the pathophysiology of Alzheimer's disease (AD) and related
dementias is the decline of plasmalogens, a key glycerophospholipid required for normal …

Plasmalogen in the brain: Effects on cognitive functions and behaviors attributable to its properties

J Udagawa, K Hino - Brain research bulletin, 2022 - Elsevier
Ether phospholipid compositions are altered in the plasma or brain of patients with brain
disorders, such as Alzheimer and Parkinson's disease, including those with psychiatric …

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease

S Paul, GI Lancaster, PJ Meikle - Progress in lipid research, 2019 - Elsevier
Plasmalogens are a class of membrane glycerophospholipids with unique properties. They
contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and …

[HTML][HTML] Plasmalogens eliminate aging-associated synaptic defects and microglia-mediated neuroinflammation in mice

J Gu, L Chen, R Sun, JL Wang, J Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Neurodegeneration is a pathological condition in which nervous system or neuron losses its
structure, function, or both leading to progressive neural degeneration. Growing evidence …

Human and great ape red blood cells differ in plasmalogen levels and composition

AB Moser, SJ Steinberg, PA Watkins, HW Moser… - Lipids in health and …, 2011 - Springer
Background Plasmalogens are ether phospholipids required for normal mammalian
developmental, physiological, and cognitive functions. They have been proposed to act as …

Oral supplementation of an alkylglycerol mix comprising different alkyl chains effectively modulates multiple endogenous plasmalogen species in mice

S Paul, AA Rasmiena, K Huynh, AAT Smith, NA Mellett… - Metabolites, 2021 - mdpi.com
Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with
numerous biological functions and are thought to have protective effects against metabolic …

Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease

PL Wood, T Smith, N Lane, MA Khan… - Lipids in health and …, 2011 - Springer
Introduction Docosahexaenoic acid (DHA) and DHA-containing ethanolamine
plasmalogens (PlsEtn) are decreased in the brain, liver and the circulation in Alzheimer's …

Book review: plasmalogens: workhorse lipids of membranes in normal and injured neurons and glia

AA Farooqui, LA Horrocks - The Neuroscientist, 2001 - journals.sagepub.com
Plasmalogens are unique glycerophospholipids because they have an enol ether double
bond at the sn-1 position of the glycerol backbone. They are found in all mammalian tissues …

Circulating plasmalogen levels and Alzheimer disease assessment scale–cognitive scores in Alzheimer patients

PL Wood, R Mankidy, S Ritchie, D Heath… - Journal of Psychiatry and …, 2010 - jpn.ca
Background: Plasmalogens, which are key structural phospholipids in brain membranes, are
decreased in the brain and serum of patients with Alzheimer disease (AD). We performed …