Aryl hydrocarbon receptor (AHR) ligands as selective AHR modulators (SAhRMs)

S Safe, U Jin, H Park, RS Chapkin… - International journal of …, 2020 - mdpi.com
The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that
bound and mediated the toxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) …

Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies

S Safe, H Han, J Goldsby, K Mohankumar… - Current opinion in …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) binds structurally diverse ligands that vary from the
environmental toxicant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to AhR-active …

Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art

L Stejskalova, Z Dvorak, P Pavek - Current drug metabolism, 2011 - ingentaconnect.com
Aryl hydrocarbon receptor (AhR) is an important transcriptional regulator of drug
metabolizing enzymes that dominantly controls the expression of cytochrome P450 CYP1 …

The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function

T Haarmann-Stemmann, J Abel - 2006 - degruyter.com
The arylhydrocarbon receptor (AhR) pathway is known to be critical for cellular events,
especially for those evoked by several environmental chemicals such as 2, 3, 7, 8 …

An overview of aryl hydrocarbon receptor ligands in the Last two decades (2002–2022): A medicinal chemistry perspective

L Lin, Y Dai, Y Xia - European Journal of Medicinal Chemistry, 2022 - Elsevier
The aryl hydrocarbon receptor (AhR), discovered 46 years ago, is a transcript factor member
of the basic helix-loop-helix Per-ARNT-SIM (bHLH-PAS) family deeply implicated in health …

Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths

L Sládeková, S Mani, Z Dvořák - Biochemical Pharmacology, 2023 - Elsevier
The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription
factors family. This receptor has a central role in determining host physiology and a variety of …

The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value

ÁC Roman, JM Carvajal-Gonzalez, JM Merino… - Pharmacology & …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …

Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor

EY Choi, H Lee, RWC Dingle, KB Kim… - Molecular pharmacology, 2012 - ASPET
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates
genes involved in drug/xenobiotic metabolism, cell cycle progression, cell fate …

The aryl hydrocarbon receptor and the maintenance of lung health

N Guerrina, H Traboulsi, DH Eidelman… - International journal of …, 2018 - mdpi.com
Much of what is known about the Aryl Hydrocarbon Receptor (AhR) centers on its ability to
mediate the deleterious effects of the environmental toxicant 2, 3, 7, 8-tetrachlorodibenzo-p …

Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions

KW Bock, C Köhle - Biochemical pharmacology, 2006 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of
the bHLH/PAS (basic Helix-Loop-Helix/Per-Arnt-Sim) family of chemosensors and …