Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …

Proper development of the skeleton in utero and during growth requires mechanical
stimulation. Loading results in adaptive changes in bone that strengthen bone structure …

The skeleton's primary mechanical function is to provide rigid levers for muscles to act
against as they hold the body upright in defiance of gravity. Many bones are exposed to …

Mechanical stimulation has a critical role in the development and maintenance of the
skeleton. This function requires the perception of extracellular stimuli as well as their …

The human skeleton is a miracle of engineering, combining both toughness and light weight.
It does so because bones possess cellular mechanisms wherein external mechanical loads …

Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment.
Increases in strain lead to increased bone mass acquisition, whereas decreases in strain …

The skeleton has the ability to perfectly adapt to external forces of the operating
environment, by altering its morphology and metabolism in order to meet different needs …

Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Bone tissue forms and is remodeled in response to the mechanical forces that it
experiences, a phenomenon described by Wolff's Law. Mechanically induced formation and …