PK/PD modelling will play an increasingly important role in drug development, because it
will identify key properties of a drug in vivo, allowing the characterization and prediction of …

To help identify the role of modelling and simulation in the development of anti-cancer
agents, their main advantages and the obstacles to their rational use, an expert meeting was …

In this paper, we review multiscale modeling for cancer treatment with the incorporation of
drug effects from an applied system's pharmacology perspective. Both the classical …

Significant scientific advances in biomedical research have expanded our knowledge of the
molecular basis of carcinogenesis, mechanisms of cancer growth, and the importance of the …

Prior to 1970s, development and regulation of new drugs was devoid of a fully quantitative,
pathophysiological conceptual foundation. Malcolm Rowland pioneered, in collaboration …

Pharmacokinetic/pharmacodynamic (PK/PD) modeling & simulation (M&S) provides
quantitative assessment of dose/exposure-response relationships with extensive …

Highlights•Mathematical models can help discover new drug targets for cancer.•Network-
based modeling can reveal promising single or combinatorial drug targets.•Multiscale …

In an era when molecular and targeted anticancer therapeutics is a major focus and when
understanding drug dynamics in tumor is critical, it seems advantageous to be able to relate …

Lack of predictability of clinical efficacy and safety is an important problem facing
pharmaceutical research today. Translational PK–PD has the ability to integrate data …

Model‐informed drug development (MIDD) approaches have rapidly advanced in drug
development in recent years. Additionally, the Prescription Drug User Fee Act (PDUFA) VI …