Preclinical in vivo studies form the cornerstone of drug development and translation,
bridging in vitro experiments with first-in-human trials. However, despite the utility of animal …

There is broad recognition, within the pharmaceutical industry that the drug development
process, especially the clinical part of it, needs considerable improvement to cope with rapid …

Despite advances in biomedical research that have deepened our understanding of cancer
hallmarks, resulting in the discovery and development of targeted therapies, the success …

Since the pioneering work of Haggard and Teorell in the first half of the 20th century, and of
Bischoff and Dedrick in the late 1960s, physiologically based pharmacokinetic (PBPK) …

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations The first book
dedicated to the emerging field of physiologically based pharmacokinetic modeling (PBPK) …

Simple Summary Mathematical and computational models, such as quantitative systems
pharmacology (QSP) models, are becoming a popular tool in drug discovery. The …

Population modeling of tumor size dynamics has recently emerged as an important tool in
pharmacometric research. A series of new mixed‐effects models have been reported …

Highlights•Preclinical pharmacokinetic-pharmacodynamic modeling (PK-PD) is an important
translational tool to understand drug efficacy in the pharmaceutical industry.•Applications of …

Translational models directly relating drug response specific processes that can be
observed in vitro to their in vivo role in cancer patients constitute a crucial part of the …

We developed a detailed, whole-body physiologically based pharmacokinetic (PBPK)
modeling tool for calculating the distribution of pharmaceutical agents in the various tissues …