The application of physiologically based pharmacokinetic (PBPK) modeling has developed
rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery …

Drug delivery schedules are key factors in the efficacy of cancer therapies, and
mathematical modeling of population dynamics and treatment responses can be applied to …

The present paper proposes a modeling and simulation strategy for the prediction of
pharmacokinetics (PK) of drug candidates by using currently available in silico and in vitro …

Drug delivery to solid tumour involves multiple physiological, biochemical and biophysical
processes taking place across a wide range of length and time scales. The therapeutic …

Quantitative systems pharmacology (QSP) models and spatial agent-based models (ABM)
are powerful and efficient approaches for the analysis of biological systems and for clinical …

Physiology based pharmacokinetic (PBPK) modeling and simulation is a useful method for
prediction of biodistribution of both macromolecules and small molecules. It can enhance …

Physiology-based pharmacokinetic (PBPK) modeling is well recognized as a technology for
mechanistically simulating and predicting the fate of substances in a mammalian body …

Quantitative systems pharmacology (QSP), a mechanistically oriented form of drug and
disease modeling, seeks to address a diverse set of problems in the discovery and …

Highlights•PBPK modeling bridges drug properties and PK behaviours in drug discovery
and development.•The PBPK is often used in oral formulation development, to address …

Pharmacokinetic (PK) studies improve the design of dosing regimens in preclinical and
clinical settings. In complex diseases like cancer, single-agent approaches are often …