Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to
infection. Sepsis is a global burden killing~ 11 million persons annually. In December 2019 …

Balanced immune regulation is crucial for recognizing an invading pathogen, its killing, and
elimination. Toll‐like receptors (TLRs) are the key regulators of the innate immune system. It …

Cytokine storm is suggested as one of the major pathological characteristics of SARS-CoV-2
infection, although the mechanism for initiation of a hyper-inflammatory response, and multi …

Introduction Mediators of immunity and inflammation are playing a crucial role in COVID-19
pathogenesis and complications as demonstrated by several genetic and clinical studies …

Abstract Purpose The Coronavirus disease 2019 (COVID-19) pandemic is one of the most
devastating global problems. Regarding the lack of disease-specific treatments, repurposing …

SARS-CoV-2 is a biphasic illness characterized by a first flu-like phase, followed by a
pulmonary and systemic disease, in which a dysregulated cytokine storm may lead to acute …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a
pandemic disease (COVID-19) that has spread globally causing more than 30,000 deaths …

Tylophorine-based compounds exert broad spectral, potent inhibition of coronaviruses. NF-
κB activation is a common pro-inflammatory response of host cells to viral infection. The …

Since the beginning of the pandemic, numerous national and international clinical trials
have been conducted with a large number of drugs. Many of them are intended for the …

Presently, we need more therapeutic molecules for this COVID-19 outbreak. The severity
and mortality of the disease is associated with a high level of release of cytokine in the …