Abstract Analysis of chromatin accessibility can reveal transcriptional regulatory sequences,
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …

During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Joint profiling of chromatin accessibility and gene expression from the same single cell
provides critical information about cell types in a tissue and cell states during a dynamic …

The brain is a complex tissue whose function relies on coordinated anatomical and
molecular features. However, the molecular annotation of the spatial organization of the …

INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

Here we present a comprehensive map of the accessible chromatin landscape of the mouse
hippocampus at single-cell resolution. Substantial advances of this work include the …

Simultaneous profiling of transcriptome and chromatin accessibility within single cells is a
powerful approach to dissect gene regulatory programs in complex tissues. However …

Neuronal activity-induced gene expression modulates the function and plasticity of the
nervous system. It is unknown whether and to what extent neuronal activity may trigger …

High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in
complex tissues, however, spatial orientation is lost. Here, we present single-cell …

Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …