V-ATPase in cancer: mechanistic insights and therapeutic potentials
T Chen, X Lin, S Lu, B Li - Cell Communication and Signaling, 2024 - Springer
Abstract Vacuolar-type H+-ATPase (V-ATPase) is a crucial proton pump that plays an
essential role in maintaining intracellular pH homeostasis and a variety of physiological …
essential role in maintaining intracellular pH homeostasis and a variety of physiological …
The function of V-ATPases in cancer
L Stransky, K Cotter, M Forgac - Physiological reviews, 2016 - journals.physiology.org
The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis
to proton transport into intracellular compartments and across the plasma membrane. They …
to proton transport into intracellular compartments and across the plasma membrane. They …
Vacuolar H+-ATPase signaling pathway in cancer
S R. Sennoune… - Current Protein and …, 2012 - benthamdirect.com
Up-regulated aerobic glycolysis is a hallmark of malignant cancers. Little is understood
about the reasons why malignant tumors up-regulate glycolysis and acidify their …
about the reasons why malignant tumors up-regulate glycolysis and acidify their …
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
B Whitton, H Okamoto, G Packham… - Cancer medicine, 2018 - Wiley Online Library
Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …
The V-ATPases in cancer and cell death
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …
[HTML][HTML] The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
Abstract The vacuolar H+ ATPase (V-ATPase) is a proton pump responsible for acidification
of cellular microenvironments, an activity exploited by tumors to survive, proliferate and …
of cellular microenvironments, an activity exploited by tumors to survive, proliferate and …
Recent insights into the structure, regulation, and function of the V-ATPases
K Cotter, L Stransky, C McGuire, M Forgac - Trends in biochemical …, 2015 - cell.com
The vacuolar (H+)-ATPases (V-ATPases) are ATP-dependent proton pumps that acidify
intracellular compartments and are also present at the plasma membrane. They function in …
intracellular compartments and are also present at the plasma membrane. They function in …
[HTML][HTML] Pharmacological targeting of vacuolar H+-ATPase via subunit V1G combats multidrug-resistant cancer
Y Wang, L Zhang, Y Wei, W Huang, L Li, A Wu… - Cell chemical …, 2020 - cell.com
Multidrug resistance (MDR) in cancer remains a major challenge for the success of
chemotherapy. Natural products have been a rich source for the discovery of drugs against …
chemotherapy. Natural products have been a rich source for the discovery of drugs against …
The curious case of vacuolar ATPase: regulation of signaling pathways
S Pamarthy, A Kulshrestha, GK Katara, KD Beaman - Molecular cancer, 2018 - Springer
Abstract The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the
intracellular and extracellular pH of cells. The structure of V-ATPase has been highly …
intracellular and extracellular pH of cells. The structure of V-ATPase has been highly …
[HTML][HTML] Vacuolar ATPase 'a2'isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer
Tumor associated vacuolar H+-ATPases (V-ATPases) are multi-subunit proton pumps that
acidify tumor microenvironment, thereby promoting tumor invasion. Subunit 'a'of its V0 …
acidify tumor microenvironment, thereby promoting tumor invasion. Subunit 'a'of its V0 …