Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

V Dussupt, RS Sankhala, L Mendez-Rivera… - Nature …, 2021 - nature.com
Prevention of viral escape and increased coverage against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal …

[PDF][PDF] Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

N Suryadevara, S Shrihari, P Gilchuk, LA VanBlargan… - Cell, 2021 - cell.com
Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike
(S) protein receptor-binding domain and block virus interactions with the cellular receptor …

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

H Yao, Y Sun, YQ Deng, N Wang, Y Tan, NN Zhang… - Cell research, 2021 - nature.com
Structural principles underlying the composition and synergistic mechanisms of protective
monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity …

SARS-CoV-2 spike S2-specific neutralizing antibodies

CJ Li, SC Chang - Emerging Microbes & Infections, 2023 - Taylor & Francis
Since the onset of the coronavirus disease 2019 (COVID-19), numerous neutralizing
antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[PDF][PDF] Identification of human single-domain antibodies against SARS-CoV-2

Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
The worldwide spread of COVID-19 highlights the need for an efficient approach to rapidly
develop therapeutics and prophylactics against SARS-CoV-2. The SARS-CoV-2 spike …

[PDF][PDF] Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

TF Custódio, H Das, DJ Sheward, L Hanke… - Nature …, 2020 - nature.com
The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic
neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19 …

Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein

S Xu, Y Wang, Y Wang, C Zhang, Q Hong… - Emerging Microbes & …, 2022 - Taylor & Francis
The emergence of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern threatens the efficacy of currently approved vaccines and authorized …

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 …

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

E Shrock, E Fujimura, T Kula, RT Timms, IH Lee… - Science, 2020 - science.org
INTRODUCTION A systematic characterization of the humoral response to severe acute
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …