This study aimed to investigate the protective effect of angiotensin converting enzyme 2
(ACE2) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). After generating ALI …

Acute respiratory distress syndrome (ARDS) caused by severe sepsis remains a major
challenge in intensive care medicine. ACE2 has been shown to protect against lung injury …

Activation of the renin-angiotensin system (angiotensin-converting enzyme
[ACE]/angiotensin II [Ang II] and angiotensin-converting enzyme 2 [ACE2]/Ang-1–7) has …

Abstract ACE2 and Ang–(1–7) have important roles in preventing acute lung injury.
However, it is not clear whether upregulation of the ACE2/Ang–(1–7)/Mas axis prevents LPS …

Angiotensin II (Ang II) plays an important role in inflammatory process. Acute lung injury
(ALI), an inflammatory disorder of the lung, is commonly associated with endotoxemia; …

Objective To investigate the role of angiotensin-converting enzyme 2 (ACE2) in hyperoxic
lung injury. Methods Adult mice were exposed to 95% O2 for 72 h to induce hyperoxic lung …

Despite substantial progress, mortality and morbidity of the acute respiratory distress
syndrome (ARDS), a severe form of acute lung injury (ALI), remain unacceptably high. There …

Abstract Angiotensin-converting enzyme 2 (ACE2) is a potent negative regulator capable of
restraining overactivation of the renin–angiotensin system, which contributes to exuberant …

Inflammation-mediated abnormalities in the renin-angiotensin system (RAS) and expression
of matrix metalloproteinases (MMPs) are implicated in the pathogenesis of lung injury …

Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase with important
functions in the renin-angiotensin system and plays a critical role in inflammatory lung …