Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

S Wang, Y Peng, R Wang, S Jiao, M Wang… - Nature …, 2020 - nature.com
Efficacious interventions are urgently needed for the treatment of COVID-19. Here, we report
a monoclonal antibody (mAb), MW05, with SARS-CoV-2 neutralizing activity by disrupting …

Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV

W Jiang, J Wang, S Jiao, C Gu, W Xu, B Chen, R Wang… - MAbs, 2021 - Taylor & Francis
The global pandemic of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in widespread social and economic disruption …

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed.
Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led …

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

D Fu, G Zhang, Y Wang, Z Zhang, H Hu, S Shen… - PLoS …, 2021 - journals.plos.org
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and …

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

R Shi, C Shan, X Duan, Z Chen, P Liu, J Song, T Song… - Nature, 2020 - nature.com
An outbreak of coronavirus disease 2019 (COVID-19),–, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spread globally. Countermeasures are needed …

Identification of SARS-CoV RBD-targeting monoclonal antibodies with cross-reactive or neutralizing activity against SARS-CoV-2

W Tai, X Zhang, Y He, S Jiang, L Du - Antiviral research, 2020 - Elsevier
Abstract SARS-CoV-2-caused COVID-19 cases are growing globally, calling for developing
effective therapeutics to control the current pandemic. SARS-CoV-2 and SARS-CoV …

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

BE Jones, PL Brown-Augsburger, KS Corbett… - Science translational …, 2021 - science.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health
threat for which preventive and therapeutic agents are urgently needed. Neutralizing …

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

J Ge, R Wang, B Ju, Q Zhang, J Sun, P Chen… - Nature …, 2021 - nature.com
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the
development of effective therapeutics and vaccines. We recently isolated a large number of …

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

Z Yang, Y Wang, Y Jin, Y Zhu, Y Wu, C Li… - Signal transduction and …, 2021 - nature.com
The current COVID-19 pandemic has heavily burdened the global public health system and
may keep simmering for years. The frequent emergence of immune escape variants have …

Fruitful neutralizing antibody pipeline brings hope to defeat SARS-Cov-2

A Renn, Y Fu, X Hu, MD Hall, A Simeonov - Trends in pharmacological …, 2020 - cell.com
With the recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2) _
infecting> 16 million people worldwide as of 28 July 2020, causing> 650 000 deaths, there …