Identifying the molecular alterations that underlie the pathophysiology of critical clinical
features of schizophrenia is an essential step in the rational development of new therapeutic …

Effective treatment for schizophrenia is still an unmet clinical need. Alleviating problems
associated with cognitive impairment and finding the root of the disease remain priorities for …

Cognitive impairment is a core feature of schizophrenia as deficits are present in the majority
of patients, frequently precede the onset of other positive symptoms, persist even with …

Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …

Mounting evidence suggests that function and connectivity of the striatum is disrupted in
schizophrenia,,,–. We have developed a new hypothesis-driven neuroimaging biomarker for …

Schizophrenia is a debilitating mental illness that affects 1% of the population. Despite
intensive study, its molecular etiology remains enigmatic. Like many common diseases …

Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …

Impaired cognitive functioning, including deficits in working memory, is considered to be a
core and disabling feature of schizophrenia that is difficult to treat. Deficits in working …

Schizophrenia has a heritability of 60-80% 1, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Schizophrenia has a heritability of 60–80%, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …