ABSTRACT DNA, or genetic, inoculation mimics aspects of attenuated vaccines in that
synthesis of specific foreign proteins is accomplished in the host. These proteins can be …

Recently, immunization techniques in which DNA constructs are introduced directly into
mammalian tissue in vivo have been developed. In theory, gene inoculation should result in …

DNA inoculation has the potential to produce antigens in a native as well as a host-"
customized" form for presentation to the immune system. As such this technology may have …

An effective immune response involves the specific recognition of and elimination of an
infectious organism at multiple levels. In this context DNA immunization can present …

Direct DNA inoculation induces immune responses through the delivery of nonreplicating
transcription units that drive the synthesis of specific foreign proteins within the inoculated …

Humoral and cellular immune responses have been produced by intramuscular vaccination
with DNA plasmids expressing HIV-1 genes, suggesting possible immunotherapeutic and …

The ability to elicit an immune response to a spectrum of human immunodeficiency virus
type 1 (HIV-1) gene products from divergent strains is a desirable feature of an AIDS …

Control of the worldwide AIDS epidemic will only be achieved with a safe and effective
prophylactic HIV-1 vaccine. DNA vaccination has recently emerged as a promising vaccine …

This article reviews advances in the field of human immunodeficiency virus type 1 (HIV-1)
and AIDS vaccine development over the last decade, with an emphasis on the DNA …

Novel approaches for the generation of more effective vaccines for HIV-1 are of significant
importance. In this report we analyze the immunogenicity and efficacy of an HIV-1 DNA …