[HTML][HTML] RdRp inhibitors and COVID-19: Is molnupiravir a good option?

SMR Hashemian, MH Pourhanifeh, MR Hamblin… - Biomedicine & …, 2022 - Elsevier
Rapid changes in the viral genome allow viruses to evade threats posed by the host immune
response or antiviral drugs, and can lead to viral persistence in the host cells. RNA …

Randomized trial of molnupiravir or placebo in patients hospitalized with Covid-19

JR Arribas, S Bhagani, SM Lobo, I Khaertynova… - NEJM …, 2022 - evidence.nejm.org
Background Molnupiravir is an oral prodrug of β-d-N4-hydroxycytidine, active against SARS-
CoV-2 in vitro and in animal models. We report data from the phase 2 component of MOVe …

[HTML][HTML] Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance

R Flisiak, D Zarębska-Michaluk, M Rogalska… - Pharmacological …, 2022 - Springer
Background The real-world effectiveness of molnupiravir (MOL) during the dominance of
Omicron SARS-CoV-2 lineage is urgently needed since the available data relate to the …

[HTML][HTML] Molnupiravir: from hope to epic fail?

D Focosi - Viruses, 2022 - mdpi.com
Molnupiravir has been the first oral antiviral authorized for COVID-19 outpatients, reporting
extraordinary sales and preserved in vitro efficacy against Omicron sublineages so far …

Effectiveness of COVID-19 treatment with nirmatrelvir–ritonavir or molnupiravir among US veterans: target trial emulation studies with one-month and six-month …

KL Bajema, K Berry, E Streja, N Rajeevan… - Annals of internal …, 2023 - acpjournals.org
Background: Information about the effectiveness of oral antivirals in preventing short-and
long-term COVID-19–related outcomes in the setting of Omicron variant transmission and …

[HTML][HTML] The emergence of powerful oral anti-COVID-19 drugs in the post-vaccine era

H Fan, F Lou, J Fan, M Li, Y Tong - The Lancet Microbe, 2022 - thelancet.com
The quest for effective drugs to treat COVID-19 has been a priority since the outbreak of the
disease. The clinical application of remdesivir has been greatly restricted by the need for …

[PDF][PDF] Efficacy of Molnupiravir for the treatment of mild or moderate COVID-19 in adults: a meta-analysis

K Benaicha, RR Khenhrani, M Veer, S Devi… - Cureus, 2023 - cureus.com
The aim of this meta-analysis is to evaluate the efficacy of molnupiravir among mild or
moderate COVID-19 patients. This meta-analysis was reported according to the guidelines …

[HTML][HTML] Clinical efficacy of antivirals against novel coronavirus (COVID-19): A review

S Jomah, SMB Asdaq, MJ Al-Yamani - Journal of infection and public health, 2020 - Elsevier
The unprecedented challenge faced by mankind due to emergence of coronavirus 2019
(COVID-19) pandemic has obligated researchers across the globe to develop effective …

[HTML][HTML] Repurposing molnupiravir for COVID-19: the mechanisms of antiviral activity

AJW Yip, ZY Low, VTK Chow, SK Lal - Viruses, 2022 - mdpi.com
Molnupiravir is a β-d-N4-hydroxycytidine-5′-isopropyl ester (NHC) compound that exerts
antiviral activity against various RNA viruses such as influenza, SARS, and Ebola viruses …

[HTML][HTML] Lopinavir-ritonavir in the treatment of COVID-19: a dynamic systematic benefit-risk assessment

V Osborne, M Davies, S Lane, A Evans, J Denyer… - Drug Safety, 2020 - Springer
Introduction and Objective COVID-19 is an ongoing, global public health crisis for which safe
and effective treatments need to be identified. The benefit-risk balance for the use of …